Syndromic orbital border hypoplasia is a rare disorder observed in two families to date and characterized by agenesis of the orbital margin, varying defects of the lacrimal passages, hypoplasia of the palpebral skin and tarsal plates and atresia of the nasolacrimal duct. The disease is Monarch Disease Ontology entry MONDO_0008138 (syndromic orbital border hypoplasia). Also known as: Urrets-Zavalia syndrome.