Osteogenesis imperfecta type II is a lethal type of osteogenesis imperfecta (OI), a genetic disorder characterized by increased bone fragility, low bone mass and susceptibility to bone fractures. Patients with type II present multiple rib and long bone fractures at birth, marked deformities, broad long bones, low density on skull X-rays, and dark sclera. The disease is osteogenesis imperfecta type 2 (MONDO_0008147). Also known as: OI type 2, OI2, Vrolik type of osteogenesis imperfecta, lethal osteogenesis imperfecta, osteogenesis imperfecta type II, perinatal lethal osteogenesis imperfecta congenita.