multicentric carpo-tarsal osteolysis with or without nephropathy (MONDO_0008152) can be described as follows. Idiopathic multicentric osteolysis is a very rare syndrome characterized by progressive loss of bone, usually the capsal and tarsal bones, resulting in deformity and disability, as well as chronic renal failure in many cases. The bone and renal disorders are sometimes associated with intellectual deficit and facial abnormalities. Also known as: idiopathic multicentric osteolysis with or without nephropathy.