extramammary Paget disease (MONDO_0008177) can be described as follows. A malignant neoplasm in which there is infiltration of the skin by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli (Paget cells). It may affect the anus, penis, scrotum, and vulva. Also known as: Extramammary Paget's disease, Paget disease Extramammary, Paget's disease of skin, Paget's disease of the skin, Paget's skin disease.