Monarch Disease Ontology term MONDO_0008215 (adult-onset autosomal dominant demyelinating leukodystrophy) is a rare, slowly progressive neurological disorder involving central nervous system demyelination, leading to autonomic dysfunction, ataxia and mild cognitive impairment. Also known as: ADLD, adult-onset autosomal dominant leukodystrophy, autosomal-dominant or late-onset type Pelizaeus-Merzbacher disease, leukodystrophy, adult-onset, autosomal dominant.