polycystic liver disease 1 (MONDO_0008265) is a polycystic liver disease in which the cause of the disease is a mutation in the PRKCSH gene, and is characterized by the appearance of numerous cysts spread throughout the liver. Also known as: PCLD1, nonsyndromic congenital polycystic liver disease, nonsyndromic polycystic liver disease (disease), polycystic liver disease 1 with or without kidney cysts.