Punctate palmoplantar keratoderma type 2 is a type of isolated, punctate, hereditary palmoplantar keratoderma characterized by multiple, asymptomatic, 1 to 2 mm-long, firm, hyperkeratotic projections ("spiny keratosis") on the palms, soles and digits (typically confined to their volar and/or lateral aspects). Histopathologically, compact columnar parakeratosis over hypo- or agranular epidermis is observed. The disease is punctate palmoplantar keratoderma type 2 (Monarch Disease Ontology id MONDO_0008292). Also known as: PPKP2, PPPP, punctate palmoplantar hyperkeratosis type 2.