Hutchinson-Gilford progeria syndrome is a rare, fatal, autosomal dominant and premature aging disease, beginning in childhood and characterized by growth reduction, failure to thrive, a typical facial appearance (prominent forehead, protuberant eyes, thin nose with a beaked tip, thin lips, micrognathia and protruding ears) and distinct dermatologic features (generalized alopecia, aged-looking skin, sclerotic and dimpled skin over the abdomen and extremities, prominent cutaneous vasculature, dyspigmentation, nail hypoplasia and loss of subcutaneous fat). The disease is MONDO_0008310 (Hutchinson-Gilford progeria syndrome). Also known as: HGPS, Hutchinson Gilford syndrome, Hutchinson-Gilford disease, Hutchinson-Gilford progeria, premature senility syndrome.