thrombophilia due to thrombin defect (MONDO_0008559) is the formation of a blood clot (thrombus) in the lumen of a vein. Also known as: prothrombin thrombophilia, prothrombin-related thrombophilia, thrombophilia 1 due to thrombin defect, venous thromboembolism, susceptibility to, venous thrombosis, protection against.