thrombophilia due to activated protein C resistance (MONDO_0008560) is a hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance. Also known as: thrombophilia 2 due to activated protein C resistance.