Wolf-Hirschhorn syndrome (MONDO_0008684) (WHS) is a developmental disorder characterized by typical craniofacial features, prenatal and postnatal growth impairment, intellectual disability, severe delayed psychomotor development, seizures, and hypotonia. Also known as: 4p deletion syndrome, 4p- syndrome, Pitt syndrome, Pitt-Rogers-Danks syndrome, Wittwer syndrome, Wolf-Hirschhorn syndrome, Isolated cases, chromosome 4p16.3 deletion syndrome, distal deletion 4p.