Acrocallosal syndrome (ACS) is a polymalformative syndrome characterized by agenesis of corpus callosum (CC), distal anomalies of limbs, minor craniofacial anomalies and intellectual deficit. The disease is acrocallosal syndrome (MONDO_0008708). Also known as: ACLS, ACS, Schinzel acrocallosal syndrome, Schinzel syndrome 1.