Medium chain acyl-CoA dehydrogenase (MCAD) deficiency (MCADD) is an inborn error of mitochondrial fatty acid oxidation characterized by a rapidly progressive metabolic crisis, often presenting as hypoketotic hypoglycemia, lethargy, vomiting, seizures and coma, which can be fatal in the absence of emergency medical intervention. The disease is Monarch Disease Ontology id MONDO_0008721 (medium chain acyl-CoA dehydrogenase deficiency). Also known as: ACADM deficiency, Acyl-CoA dehydrogenase, medium chain, deficiency of, Carnitine deficiency secondary to medium-chain acyl-CoA dehydrogenase deficiency, MCAD, MCAD deficiency, MCADD, acyl-CoA dehydrogenase, medium-chain deficiency, medium chain acyl-coenzyme A dehydrogenase deficiency.