Leber congenital amaurosis 1 (MONDO_0008764) is any Leber congenital amaurosis in which the cause of the disease is a mutation in the GUCY2D gene. Also known as: GUCY2D Leber congenital amaurosis, LCA1, Leber congenital amaurosis caused by mutation in GUCY2D, Leber congenital amaurosis type 1, amaurosis congenita of Leber I.