An autosomal recessive genetic disorder caused by mutations in the ENPP1 gene, encoding ectonucleotide pyrophosphatase/phosphodiesterase family member 1. The condition is characterized by calcification and narrowing of medium- and large-sized arteries, resulting in cardiovascular complications. The disease is arterial calcification, generalized, of infancy, 1 (Monarch Disease Ontology entry MONDO_0008817). Also known as: ENPP1 arterial calcification of infancy, arterial calcification of infancy caused by mutation in ENPP1, arterial calcification, generalized, of infancy, type 1, generalised arterial calcification of infancy 1, generalized arterial calcification of infancy 1.