thromboangiitis obliterans (MONDO_0008889) is a rare inflammatory non-necrotizing vascular disease affecting the small- and medium-sized arteries and veins of the upper and lower extremities characterized by endarteritis and vaso-occlusion due to occlusive thrombus development. The development and progression of the disease is consistently associated with exposure to tobacco. Also known as: Buerger's Disease, Buerger's disease, presenile gangrene, thromboangiitis obliterans [Buerger's disease].