CHARGE syndrome (Monarch Disease Ontology entry MONDO_0008965) is a multiple congenital anomaly syndrome characterized by the variable combination of multiple anomalies, mainly Coloboma; Choanal atresia/stenosis; Cranial nerve dysfunction; Characteristic ear anomalies (known as the major 4 C's). Also known as: CHARGE association, Hall-Hittner syndrome, coloboma, heart defects, choanal atresia, retardation of Growth and development, genital abnormalities, and Ear anomalies association, coloboma, heart malformation, choanal atresia, retardation of Growth and development, genital abnormalities, and Ear malformations (CHARGE) association, coloboma-heart defects-atresia choanae-retardation of growth and development-genitourinary problems-ear abnormalities syndrome.