Pfeiffer-type cardiocranial syndrome is an extremely rare disorder recognized in less than ten patients worldwide and characterized by a congenital heart defect, sagittal craniosynostosis and severe developmental delay (growth retardation and intellectual deficit). The disease is Monarch Disease Ontology identifier MONDO_0009036 (cardiocranial syndrome, Pfeiffer type). Also known as: Pfeiffer-Singer-Zschiesche syndrome, craniosynostosis-congenital heart disease-intellectual disability syndrome, sagittal craniostenosis with congenital heart disease, mental deficiency and mandibular ankylosis.