Cushing syndrome due to macronodular adrenal hyperplasia (MONDO_0009049) is a rare adrenal Cushing syndrome characterized by bilateral benign adrenal macronodules (>1 cm) that potentially produce autonomously variable levels of cortisol excess. Although in most cases are ACTH-independent, non-suppressed ACTH levels have been described. Also known as: ACTH-independent macronodular adrenal hyperplasia, primary bilateral macronodular adrenal hyperplasia.