polycystic lipomembranous osteodysplasia with sclerosing leukoencephaly (MONDO_0009092) is a rare inherited leukodystrophy characterized by progressive presenile dementia associated with recurrent bone fractures due to polycystic osseous lesions of the lower and upper extremities. Also known as: NHD, Nasu-Hakola disease, PLO-SL, PLOSL, polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy, presenile dementia with bone cysts, progressive dementia with lipomembranous polycystic osteodysplasia; brain-bone-fat disease.