A very rare primary monoamine neurotransmitter synthesis disorder with norepinephrine and adrenaline deficiency that leads to young-onset severe orthostatic hypotension and eyelid ptosis. The disease is Monarch Disease Ontology term MONDO_0009123 (orthostatic hypotension 1). Also known as: congenital dopamine beta-hydroxylase deficiency, dopamine beta-hydroxylase deficiency, noradrenaline deficiency, norepinephrine deficiency, orthostatic hypotension 1, due to DBH deficiency.