Any hypothyroidism, congenital, nongoitrous in which the cause of the disease is a mutation in the NKX2-5 gene. The disease is hypothyroidism, congenital, nongoitrous, 5 (MONDO_0009154, a Monarch Disease Ontology entry). Also known as: CHNG5, NKX2-5 hypothyroidism, congenital, nongoitrous, hypothyroidism, congenital nongoitrous, 5, hypothyroidism, congenital, nongoitrous caused by mutation in NKX2-5, hypothyroidism, congenital, nongoitrous, type 5.