A basal subtype of epidermolysis bullosa simplex (EBS) characterized by generalized blistering associated with muscular dystrophy. The disease is Monarch Disease Ontology entry MONDO_0009181 (epidermolysis bullosa simplex 5B, with muscular dystrophy). Also known as: EBS-MD, epidermolysis bullosa simplex and limb-girdle muscular dystrophy, epidermolysis bullosa simplex with muscular dystrophy, limb-girdle muscular dystrophy with epidermolysis bullosa simplex.