Any combined deficiency of factor V and factor VIII in which the cause of the disease is a mutation in the LMAN1 gene. The disease is factor V and factor VIII, combined deficiency of, type 1 (MONDO_0009206). Also known as: LMAN1 combined deficiency of factor V and factor VIII, combined deficiency of factor V and factor VIII caused by mutation in LMAN1, combined factor V and VIII deficiency, factor 5 and Factor VIII, combined deficiency of, 1.