Triple A syndrome is a very rare multisystem disease characterized by adrenal insufficiency with isolated glucocorticoid deficiency, achalasia, alacrima, autonomic dysfunction and neurodegeneration. The disease is triple-A syndrome (MONDO_0009279). Also known as: 2A syndrome, 3A syndrome, 4A syndrome, AAA syndrome, Allgrove syndrome, Double A syndrome, achalasia-addisonianism-alacrima syndrome, achalasia-addisonianism-alacrimia syndrome.