lipodystrophy due to peptidic growth factors deficiency (MONDO_0009312, a Monarch Disease Ontology entry) can be described as follows. Deficiency of the peptidic growth factors is characterized by loss of subcutaneous fat layers on the limbs, lipodystrophy in the face and trunk and scleroderma-like skin disorders (thickened skin on the palms and soles and skin pigment changes on the limbs and trunk). Also known as: Hoepffner-Dreyer-Reimers syndrome, Werner-like syndrome due to combined growth factor deficiency, combined insulin, insulin-like growth factor 1 (IGF1) and epidermal growth factor (EGF) deficiency.