Classical Hodgkin lymphoma (CHL) is a B-cell lymphoma characterized histologically by the presence of large mononuclear Hodgkin cells and multinucleated Reed-Sternberg (HRS) cells. The disease is classic Hodgkin lymphoma (Monarch Disease Ontology identifier MONDO_0009348). Also known as: classic Hodgkin disease, classical Hodgkin lymphoma, classical Hodgkin's lymphoma.