A syndrome characterized by Potter sequence, heart defect, cleft palate, polydactyly, and skeletal defects. The disease is Holzgreve-Wagner-Rehder syndrome (Monarch Disease Ontology entry MONDO_0009350). Also known as: Holzgreve Wagner Rehder syndrome, Holzgreve syndrome, cleft palate-Potter sequence-congenital heart anomalies-mesoaxial polydactyly-multiple malformations syndrome.