immunodeficiency-centromeric instability-facial anomalies syndrome 1 (Monarch Disease Ontology identifier MONDO_0009454) is any immunodeficiency-centromeric instability-facial anomalies syndrome in which the cause of the disease is a mutation in the DNMT3B gene. Also known as: DNMT3B immunodeficiency-centromeric instability-facial anomalies syndrome, ICF syndrome 1, immunodeficiency-centromeric instability-Facial anomalies syndrome type 1, immunodeficiency-centromeric instability-facial anomalies syndrome caused by mutation in DNMT3B, immunodeficiency-centromeric instability-facial anomalies syndrome type 1.