mal de Meleda (MONDO_0009552, a Monarch Disease Ontology entry) can be described as follows. Mal de Melada (MdM) is a diffuse palmoplantar keratoderma initially reported from of the Island of Meleda characterized by symmetric palmoplantar hyperkeratosis that progressively extends to the dorsal surfaces of hands and feet (transgradiens). The disease can be associated to hyperhidrosis, lichenoid plaques and perioral erythema. Also known as: Meleda Disease, Meleda disease, keratosis palmoplantaris transgrediens of Siemens, transgrediens palmoplantar keratoderma of Siemens.