A rare, early-onset and life-threatening, multiple carboxylase deficiency that when left untreated, is characterized by vomiting, tachypnea, irritability, lethargy, exfoliative dermatitis, and seizures that can worsen to coma and death. The disease is Monarch Disease Ontology term MONDO_0009666 (holocarboxylase synthetase deficiency). Also known as: biotin-(propionyl-CoA-carboxylase) ligase deficiency, early-onset multiple carboxylase deficiency, holocarboxylase synthase deficiency, multiple carboxylase deficiency - neonatal onset, neonatal multiple carboxylase deficiency.