Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension. The disease is MONDO_0009692 (primary myelofibrosis). Also known as: AMM, Agnogenic myeloid metaplasia, CIMF, aleukemic myelosis, bone marrow fibrosis, chronic idiopathic myelofibrosis, idiopathic bone marrow fibrosis, idiopathic myelofibrosis.