Generalized osteosclerosis with periosteal bone formation, characteristic facial dysmorphism, brain abnormalities including intracerebral calcifications, and neonatal lethal course. The disease is lethal osteosclerotic bone dysplasia (MONDO_0009821, a Monarch Disease Ontology identifier). Also known as: RAINE syndrome, Raine syndrome, osteomalacia, sclerosing, with cerebral calcification, osteosclerotic bone dysplasia, lethal.