A rare neurometabolic disease characterized by recurrent intractable seizures in the prenatal, neonatal and postnatal period that are resistant to anti-epileptic drugs (AEDs) but that are responsive to pharmacological dosages of pyridoxine (vitamin B6). The disease is MONDO_0009945 (pyridoxine-dependent epilepsy). Also known as: antiquitin deficiency, vitamin B6-dependent seizures.