MONDO_0010079 (Canavan disease) is a neurodegenerative disorder; its spectrum varies between severe forms with leukodystrophy, macrocephaly and severe developmental delay, and a very rare mild/juvenile form characterized by mild developmental delay. Also known as: ACY2 deficiency, Canavan-VAN Bogaert-Bertrand disease, aminoacylase 2 deficiency, aspartoacylase deficiency, spongy degeneration of central nervous system, spongy degeneration of the brain.