A rare, autosomal recessive inherited disorder usually caused by mutations in the THRB gene. It is characterized by a defective physiological resistance to thyroid hormones, resulting in the elevation of thyroxin and triiodothyronine in the serum. The disease is Monarch Disease Ontology id MONDO_0010131 (thyroid hormone resistance, generalized, autosomal recessive). Also known as: thyroid hormone resistance, autosomal recessive.