Type 3 von Willebrand disease (type 3 VWD) is the most severe form of VWD characterized by a bleeding disorder associated with a total or near-total absence of Willebrand factor (von Willebrand factor; VWF) in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII (FVIII). The disease is von Willebrand disease 3 (MONDO_0010191, a Monarch Disease Ontology entry). Also known as: VWD type 3, VWD3, von Willebrand disease type 3, von Willebrand disease type III, von Willebrand's disease 3, von Willebrand's disease type 3.