A subtype of Waardenburg syndrome type 4 (Waardenburg-Shah syndrome) caused by mutations in EDNRB. The disease is Waardenburg syndrome type 4A (MONDO_0010192). Also known as: EDNRB Waardenburg syndrome, WS4A, Waardenburg syndrome caused by mutation in EDNRB, Waardenburg syndrome type IVA, Waardenburg syndrome with Hirschsprung disease type 4A.