An autosomal recessive genetic disorder caused by mutations in the DDB2 gene. This disease exhibits the mildest degree of sun sensitivity of all xeroderma pigmentosum complementation groups, although individuals are at high risk for skin cancer. The disease is xeroderma pigmentosum group E (Monarch Disease Ontology identifier MONDO_0010213). Also known as: XP group E, XP-E, XP5, XPE, xeroderma pigmentosum V, xeroderma pigmentosum group type E, xeroderma pigmentosum, complementation group type E, xeroderma pigmentosum, group E, DDB-negative subtype.