hereditary spastic paraplegia 16 (MONDO_0010287, a Monarch Disease Ontology entry) is a hereditary spastic paraplegia that has material basis in variation in the chromosome region Xq11.2. Also known as: SPG16, X-linked spastic paraplegia 16, X-linked spastic paraplegia type 16, hereditary spastic paraplegia type 16, spastic paraplegia 16, X-linked, complicated, X-linked recessive.