Mononen-Karnes-Senac syndrome is characterized by skeletal dysplasia associated with finger malformations (brachydactyly with short and abducted thumbs, short index fingers, and markedly short and abducted great toes), variable mild short stature, and mild bowleg with overgrowth of the fibula. It has been described in two males, their mothers, and a maternal aunt. Females are less severely affected than males. X-linked dominant inheritance is suggested. The disease is MONDO_0010538 (Mononen-Karnes-Senac syndrome). Also known as: Mononen type brachydactyly, short and abducted thumbs and great toes, skeletal dysplasia-brachydactyly syndrome.