An extremely rare and fatal central nervous system malformation occurring during embryogenesis, presenting prenatally with holoprosencephaly and fetal hypokinesia as major features. Other manifestations include microcephaly, multiple contractures and intrauterine growth restriction. An X-linked recessive inheritance has been suggested. The disease is MONDO_0010610 (holoprosencephaly-hypokinesia-congenital contractures syndrome). Also known as: Morse-Rawnsley-Sargent syndrome, holoprosencephaly-fetal akinesia/hypokinesia sequence syndrome.