MONDO_0010689 (Charcot-Marie-Tooth disease X-linked recessive 4) can be described as follows. X-linked Charcot-Marie-Tooth disease type 4 is a rare, genetic, axonal, peripheral sensorimotor neuropathy characterized by an X-linked recessive inheritance pattern and the neonatal- to early childhood-onset of severe, slowly progressive, distal muscle weakness and atrophy (in particular of the peroneal group), as well as sensory impairment (with the lower extremities being more affected than the upper extremities), pes cavus, areflexia and hammertoes. Sensorineural hearing loss and cognitive impairment may also be associated. Females are asymptomatic and do not display the phenotype. Also known as: CMT4X, CMTX 4, CMTX4, COWCK, Charcot-Marie-Tooth disease X-linked recessive type 4, Charcot-Marie-Tooth disease with deafness and intellectual disability, Charcot-Marie-Tooth disease with deafness and mental retardation, Charcot-Marie-Tooth disease, X-linked recessive, 4.