Spastic paraplegia type 2 (SPG2) is an X-linked leukodystrophy characterized primarily by spastic gait and autonomic dysfunction. When additional central nervous system (CNS) signs, such as intellectual deficit, ataxia, or extrapyramidal signs, are present, the syndrome is referred to as complicated SPG. The disease is Monarch Disease Ontology identifier MONDO_0010733 (hereditary spastic paraplegia 2). Also known as: PLP1 hereditary spastic paraplegia, SPG2, X-linked spastic paraplegia 2, X-linked spastic paraplegia type 2, hereditary spastic paraplegia caused by mutation in PLP1, hereditary spastic paraplegia type 2, spastic gait type 2, spastic paraparesis type 2.