Monarch Disease Ontology id MONDO_0010878 (hereditary spastic paraplegia 6) can be described as follows. Autosomal dominant spastic paraplegia type 6 (SPG6) is a form of hereditary spastic paraplegia which usually presents in late adolescence or early adulthood as a pure phenotype of lower limb spasticity with hyperreflexia and extensor plantar responses, as well as mild bladder disturbances and pes cavus. Rarely, it can present as a complex phenotype with additional manifestations including epilepsy, variable peripheral neuropathy and/or memory impairment. Also known as: FSP3, NIPA1 hereditary spastic paraplegia, SPG6, autosomal dominant familial spastic paraplegia type 3, autosomal dominant spastic paraplegia 6, autosomal dominant spastic paraplegia type 6, hereditary spastic paraplegia caused by mutation in NIPA1, hereditary spastic paraplegia type 6.