acrocardiofacial syndrome (Monarch Disease Ontology identifier MONDO_0010890) can be described as follows. Acro-cardio-facial syndrome (ACFS) is a rare genetic disorder characterized by split-hand/split-foot malformation (SHFM), facial anomalies, cleft lip/palate, congenital heart defect (CHD), genital anomalies, and intellectual deficit. Also known as: ACFS, CCGE syndrome, cleft palate-cardiac defect-genital anomalies-ectrodactyly syndrome.