An autosomal dominant tumor predisposition disorder caused by pathogenic variants in the SDHAF2 gene, characterized by an increased risk of paraganglioma, particularly head and neck paragangliomas. The disease is MONDO_0011121 (pheochromocytoma/paraganglioma syndrome 2). Also known as: SDHAF2 paraganglioma, SDHAF2-related tumor predisposition, paraganglioma caused by mutation in SDHAF2, paragangliomas 2, paragangliomas type 2.