Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the SETX gene. The disease is amyotrophic lateral sclerosis type 4 (MONDO_0011223). Also known as: ALS 4, ALS4, SETX amyotrophic lateral sclerosis, amyotrophic lateral sclerosis 4, amyotrophic lateral sclerosis 4, juvenile, amyotrophic lateral sclerosis caused by mutation in SETX, dHMN with upper motor neuron signs, distal hereditary motor neuropathy with pyramidal features.