Grange syndrome is characterized by stenosis or occlusion of multiple arteries (including the renal, cerebral and abdominal vessels), hypertension, brachysyndactyly, syndactyly, increased bone fragility, and learning difficulties or borderline intellectual deficit. Congenital heart defects were also reported in some cases. The disease is Monarch Disease Ontology entry MONDO_0011243 (grange syndrome). Also known as: grange occlusive arterial syndrome, progressive arterial occlusive disease-hypertension-heart defects-bone fragility-brachysyndactyly syndrome.