A skin disease characterized by poikiloderma, hyperkeratotic nails, generalized hyperkeratosis on palms and soles, neutropenia, short stature, and recurrent pulmonary infections. It has material basis in mutation in the C16ORF57 gene on chromosome 16q13. The disease is MONDO_0011405 (poikiloderma with neutropenia). Also known as: Prurigo Nodularis, poikiloderma with neutropenia, Clericuzio type.